Varistron® is a serotonin 5-HT3 receptor antagonist used to prevent nausea and vomiting in cancer chemotherapy and postoperatively.
IM, Slow IV Injection (over 2-5 minutes), IV Infusion (over 15 minutes)
Adult:
Chemotherapy-Induced Nausea & Vomiting (Prophylaxis): IV: 0.15 mg/kg over 15 min administered 30 min before chemotherapy, then 4 and 8 hr after first dose; not to exceed 16 mg.
Postoperative Nausea & Vomiting (Prophylaxis): 4 mg IV/IM immediately before anesthesia or after procedure or 16 mg PO 1 hr before anesthesia.
Pediatric:
Chemotherapy-Induced Nausea & Vomiting (Prophylaxis):
<6 months: Safety and efficacy not established.
≥6 months: 0.15 mg/kg over 15 min administered 30 min before chemotherapy, then repeated 4 and 8 hr after first dose; not to exceed 16 mg/dose.
Postoperative Nausea & Vomiting (Prophylaxis):
1 month-12 years:
<40 kg: 0.1 mg/kg IV.
>40 kg: 4 mg IV.
>12 years: 4 mg IV/IM immediately before anesthesia or after procedure or 16 mg PO 1 hr before anesthesia.
