Vario-Mitexan (Mesna) 400mg/4m

Vario-Mitexan® is a medication used to treat and prevent toxic side effects in the urinary tract caused by certain anticancer drugs.

Solution for Injection - IV Injection and IV Infusion

Standard-Dose Ifosfamide: IV: Each mesna dose is equal to 20% of the daily ifosfamide dose and given for 3 doses: With the ifosfamide dose (hour 0), at hour 4, and at hour 8 after ifosfamide initiation (total daily mesna dose is 60% of the daily ifosfamide dose).
IV and Oral Dosing Regimen: Following an IV mesna dose equal to 20% of the daily ifosfamide dose at hour 0, administer 2 oral mesna doses, each equal to 40% of the daily ifosfamide dose and give at hour 2 and at hour 6 after ifosfamide initiation (total daily mesna dose is 100% of the daily ifosfamide dose). Note: If the oral mesna dose is vomited within 2 hours of administration, repeat the oral mesna dose or administer IV mesna.
Short Infusion Standard-Dose Ifosfamide: IV: Total mesna dose is equal to 60% of the ifosfamide dose, in 3 divided doses (each mesna dose as 20% of daily ifosfamide dose), given 15 minutes before the ifosfamide dose, and 4 and 8 hours after initiation of ifosfamide dose.
Continuous Infusion Standard-Dose Ifosfamide: IV: Mesna dose (as a bolus) is equal to 20% of the daily ifosfamide dose, followed by a continuous infusion of mesna at 40% of the daily ifosfamide dose; continue mesna infusion for 12 to 24 hours after completion of ifosfamide infusion.

• Cardiovascular: Flushing
• Central nervous system: Dizziness, drowsiness, headache, hyperesthesia, rigors
• Dermatologic: Skin rash
• Gastrointestinal: Anorexia, constipation, diarrhea, flatulence, nausea, vomiting
• Local: Injection site reaction
• Neuromuscular & skeletal: Arthralgia, back pain
• Ophthalmic: Conjunctivitis
• Respiratory: Cough, flu-like symptoms, pharyngitis, rhinitis
• Miscellaneous: Fever

There are no known significant interactions.

Store below 30 °C. Keep Vario-Mitexan® like all medicines out of the reach of children.