Martindale Category: Antidote; Bisphosphonate Derivative
Generic Name: Zoledronic Acid (as Monohydrate)
Strength: Zolvar 4mg/5ml, each concentrate contains 4 mg of Zoledronic Acid.
Classification: Antidote, Bisphosphonate Derivative
Therapeutic Use: 1. Treating high calcium levels caused by cancer.
2. Managing brittle bones in multiple myeloma.
3. Bone metastases in solid tumors.
4. Off-label use in bone loss associated with breast and prostate cancer treatments.

Zolvar is a Bisphosphonate Derivative used to treat high calcium levels caused by cancer or brittle bones caused by a cancer called multiple myeloma.

Zol-var® 4mg/5ml (Zoledronic Acid) Concentrate for solution for infusion

IV Preparation: Dilute in 100 mL of NS or D5W before administering. Infusion of solution must be completed within 24 hours of initial reconstitution. IV Administration: Infuse over at least 15 minutes, in a line separate from other medications. Ensure appropriate hydration, especially in patients on diuretics.

Acute kidney injury
Atrial fibrillation
Atypical femur fractures
Hypocalcemia
Influenza-like illness/acute phase reaction
Osteonecrosis of the jaw

IV Incompatibilities: Calcium-containing solutions (e.g., Ringer Lactate solution). For a complete list of drug interactions, use the drug interactions program provided in the patient support section.

Store ampules below 30 °C. After final dilution, use solution immediately or store at 2-8°C and do not freeze. Keep out of the reach of children.